Phenotypes Associated with This Genotype

Genotype
MGI:3653727

• Allelic Composition: Tg(Myh6-Akt1)20Anr/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:77257 )

• myocytes show significant heterogeneity in size

cardiac hypertrophy ( J:77257 )

• the heart weight/body weight ratio is 1.6-fold greater than in wild-type female littermates

heart left ventricle hypertrophy ( J:77257 )

• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal

decreased myocardial infarct size ( J:77257 )

• infarct size after coronary ligation is reduced by about 50% compared with controls

muscle

abnormal myocardial fiber morphology ( J:77257 )

• myocytes show significant heterogeneity in size

heart left ventricle hypertrophy ( J:77257 )

• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal

homeostasis/metabolism

decreased myocardial infarct size ( J:77257 )

• infarct size after coronary ligation is reduced by about 50% compared with controls

growth/size/body

cardiac hypertrophy ( J:77257 )

• the heart weight/body weight ratio is 1.6-fold greater than in wild-type female littermates

heart left ventricle hypertrophy ( J:77257 )

• exhibit left ventricle hypertrophy that is slightly less marked in females than males, however systolic ventricular function is normal