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Phenotypes Associated with This Genotype
Genotype
MGI:3653676
Allelic
Composition		 \Apoetm1Unc/\Apoetm1Unc
\Ttpatm1Far/\Ttpa+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Ttpatm1Far mutation (1 available); any Ttpa mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal vitamin E level ( J:66419 )
• chow-fed mice heterozygous for Ttpatm1Far and homozygous for Apoetm1Unc show a 24% reduction of plasma alpha-tocopherol levels relative to single Apoetm1Unc homozygotes

cardiovascular system
atherosclerotic lesions ( J:66419 )
• at 30 weeks of age, chow-fed female mice heterozygous for Ttpatm1Far and homozygous for Apoetm1Unc have 13% larger atherosclerotic lesions in the aortic arch region relative to single Apoetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory