Phenotypes Associated with This Genotype

Genotype
MGI:3653653

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ttpa^tm1Far/Ttpa^tm1Far
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphology of aortic lesions in Apoe^tm1Unc/Apoe^tm1Unc and Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far mice

homeostasis/metabolism

abnormal lipid homeostasis ( J:66419 )

• at 30 weeks of age, chow-fed double homozygous mutant females show no significant differences in total plasma cholesterol levels, HDL cholesterol levels or plasma ascorbate and urate levels relative to single Apoe^tm1Unc homozygotes

• however, double mutant females display a ~2-fold increase in total F2-isoprostane levels in the proximal and distal aorta, indicating that increased lipid peroxidation contributes to lesion development

cardiovascular system

atherosclerotic lesions ( J:66419 )

• at 30 weeks of age, chow-fed double homozygous mutant females exhibit a ~36% increase in total aortic lesion area relative to single Apoe^tm1Unc homozygotes

• specifically, double mutant females have 42% and 53% larger aortic lesions in the aortic arch and thorax region, respectively, relative to single Apoe^tm1Unc homozygotes; no differences in lesion size in the abdominal aorta are observed

• double mutant aortic root lesions exhibit more complex features, including a large necrotic core, numerous needle-shaped lucencies indicative of cholesterol crystals, and fibrous capping from smooth muscle cells