Phenotypes Associated with This Genotype

Genotype
MGI:3653641

• Allelic Composition: Kl^kl/Kl⁺
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

calcified pulmonary alveolus ( J:59775 )

• calcification of the alveoli is detected at 120 weeks of age

emphysema ( J:59775 )

• seen at 120 weeks of age

skeleton

kyphosis ( J:59775 )

• seen at 120 weeks of age

cardiovascular system

abnormal blood vessel physiology ( J:76383 )

• blood flow restoration and capillary growth are impaired following induced hindlimb ischemia

homeostasis/metabolism

decreased insulin secretion ( J:64878 )

• the pancreatic insulin content of 8 week old heterozygotes is approximately 118 ug/g, lower than the 171 mg/g in wildtype controls and higher than the 34 mg/g in homozygotes

hypoglycemia ( J:64878 )

• in oral glucose tolerance tests heterozygotes show hypoglycemia relative to wildtype controls, but not as severe as in homozygotes

decreased circulating insulin level ( J:64878 )

endocrine/exocrine glands

decreased insulin secretion ( J:64878 )

• the pancreatic insulin content of 8 week old heterozygotes is approximately 118 ug/g, lower than the 171 mg/g in wildtype controls and higher than the 34 mg/g in homozygotes

integument

alopecia ( J:59775 )

• hair loss is seen at 120 weeks of age