Analysis Tools
mortality/aging
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• 70% of homozygotes die within 1-2 hours of birth due to cleft palate; remainder die within 10-24 hours of birth from respiratory complications
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growth/size/body
cleft palate
(
J:110783
)
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• 70% of newborns have cleft palate and die within 1-2 hours of birth
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• thorax is small and narrow suggesting reduced ribcage size is reason for lung hypoplasia
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• newborn mice have smaller bones of the axial, craniofacial and appendicular skeleton
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• at E17.5 and at the newborn stage, conditional null embryos are 5% shorter than controls
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craniofacial
cleft palate
(
J:110783
)
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• 70% of newborns have cleft palate and die within 1-2 hours of birth
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skeleton
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• growth plates are significantly shortened in mutants
• in newborns, size reduction is more pronounced with disorganized arrangement of columnar chondrocytes and rounding of the chondrocytes rather than the normal flattened morphology
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• in newborns, size reduction is more pronounced with disorganized arrangement of columnar chondrocytes and rounding of the chondrocytes rather than the normal flattened morphology
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cellular
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• in culture, mutant chondrocytes show reduction of adhesion to fibronectin or collagen I by 30% or 32% respectively compared to controls
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• number of cyclin-D positive nuclei is reduced by 40% in the growth plates
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• chondrocyte proliferation in the growth plate is reduced by 29% in mutants
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respiratory system
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• remaining mutants suffer from lung hypoplasia and die due to breathing problems
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digestive/alimentary system
cleft palate
(
J:110783
)
|
• 70% of newborns have cleft palate and die within 1-2 hours of birth
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