Phenotypes Associated with This Genotype

Genotype
MGI:3653405

• Allelic Composition: Pou1f1^dw/Pou1f1^dw
• Genetic Background: DW/J Pou1f1^dw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:73731 )

• lifespan of female mice housed with normal-sized control females (caretakers) is increased by 50% (872 days) over median life span (579 days) of controls

• lifespan of male mice housed with control males is reduced by 6%, however, when transferred to female caretakers the two oldest males lived 24% longer than controls

hematopoietic system

decreased B cell number ( J:110683 )

• the frequency of B lineage cells is significantly reduced

• treatment with T4 restores B lineage deficiency

• myelopoiesis and thymopoiesis were normal

immune system

decreased B cell number ( J:110683 )

• the frequency of B lineage cells is significantly reduced

• treatment with T4 restores B lineage deficiency

• myelopoiesis and thymopoiesis were normal

endocrine/exocrine glands

increased pituitary gland apoptosis ( J:108961 )

• at 1 day of age a slight increase in apoptosis in the pituitary is found

• however, no increase in apoptosis is observed at 8 days of age

abnormal adenohypophysis morphology ( J:108961 )

• at 8 days of age there are fewer actively dividing cells in the pituitary but no abnormal increase in apoptosis

absent somatotrophs ( J:7211 )

absent lactotrophs ( J:7211 )

adenohypophysis hypoplasia ( J:108961 )

• although normal size and morphology at 1 day of age, the pituitary is smaller than normal by 11 days of age due to reduced growth of the anterior lobes

nervous system

increased pituitary gland apoptosis ( J:108961 )

• at 1 day of age a slight increase in apoptosis in the pituitary is found

• however, no increase in apoptosis is observed at 8 days of age

abnormal adenohypophysis morphology ( J:108961 )

• at 8 days of age there are fewer actively dividing cells in the pituitary but no abnormal increase in apoptosis

absent somatotrophs ( J:7211 )

absent lactotrophs ( J:7211 )

adenohypophysis hypoplasia ( J:108961 )

• although normal size and morphology at 1 day of age, the pituitary is smaller than normal by 11 days of age due to reduced growth of the anterior lobes

growth/size/body

decreased body size ( J:108961 )

• although homozygotes are the same size as control littermates at birth, they begin to be smaller at 2 weeks of age, are noticably smaller by 3 weeks of age, and are only one third to one quarter the size of normal littermates as adults

cellular

increased pituitary gland apoptosis ( J:108961 )

• at 1 day of age a slight increase in apoptosis in the pituitary is found

• however, no increase in apoptosis is observed at 8 days of age