Phenotypes Associated with This Genotype

Genotype
MGI:3652976

• Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak; Cd5^tm1Cgn/Cd5^tm1Cgn
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell clonal deletion ( J:110925 )

• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection

increased CD4-positive, alpha-beta T cell number ( J:110925 )

• CD4+ thymocytes are increased to a greater extent than in CD5 knockouts

increased CD8-positive, alpha-beta T cell number ( J:110925 )

• Cd8+ thymocytes are increased

hematopoietic system

abnormal T cell clonal deletion ( J:110925 )

• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection

increased CD4-positive, alpha-beta T cell number ( J:110925 )

• CD4+ thymocytes are increased to a greater extent than in CD5 knockouts

increased CD8-positive, alpha-beta T cell number ( J:110925 )

• Cd8+ thymocytes are increased