Phenotypes for Cd5 Cd28 MGI:3652976 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd28^tm1Mak/Cd28^tm1Mak Cd5^tm1Cgn/Cd5^tm1Cgn
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Mak mutation (13 available); any Cd28 mutation (37 available)
Cd5^tm1Cgn mutation (1 available); any Cd5 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell clonal deletion ( J:110925 )

• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection

increased CD4-positive, alpha-beta T cell number ( J:110925 )

• CD4+ thymocytes are increased to a greater extent than in CD5 knockouts

increased CD8-positive, alpha-beta T cell number ( J:110925 )

• Cd8+ thymocytes are increased

hematopoietic system