Analysis Tools
immune system
|
• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation
|
|
• null mice display defective responses to T cell independent type II antigens like TNP-Ficoll; production of IgG3 is markedly reduced
|
|
• vaccination of Dapp1-deficient mice with capsular polysaccharide from S. pneumoniae results in production of type 3 polysaccharide-specific IgM antibodies but failure to produce of type 3 polysaccharide-specific IgG3 antibodies
|
|
• wild-type mice vaccinated with live S. pneumoniae via IP injection show100% survival but all vaccinated Dapp1-deficient die
|
hematopoietic system
|
• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation
|
|
• vaccination of Dapp1-deficient mice with capsular polysaccharide from S. pneumoniae results in production of type 3 polysaccharide-specific IgM antibodies but failure to produce of type 3 polysaccharide-specific IgG3 antibodies
|
cellular
|
• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation
|
