Analysis Tools
craniofacial
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• position of the incisor apex is anterior to that seen in controls and barely extends past the third molar at P20
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• starting at P18, observe a developmental delay of molars such that at P18, the molars have not yet erupted and the roots are underdeveloped
• by P23, the first two molars have erupted, however they are still covered by adherent debris that appears to be remnants of the overlying epithelium and by P25 this debris is mostly removed, however dentin and enamel appear normal
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• exhibit a developmental delay of approximately 5 days in tooth eruption
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• at P20, the hemimandibles are small and deformed, the ventral margin radius is more acute than those of controls, far less bone is present anterior to the first molar diastema, and the overall mass of bone is reduced
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skeleton
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• position of the incisor apex is anterior to that seen in controls and barely extends past the third molar at P20
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• starting at P18, observe a developmental delay of molars such that at P18, the molars have not yet erupted and the roots are underdeveloped
• by P23, the first two molars have erupted, however they are still covered by adherent debris that appears to be remnants of the overlying epithelium and by P25 this debris is mostly removed, however dentin and enamel appear normal
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• exhibit a developmental delay of approximately 5 days in tooth eruption
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• at P20, the hemimandibles are small and deformed, the ventral margin radius is more acute than those of controls, far less bone is present anterior to the first molar diastema, and the overall mass of bone is reduced
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immune system
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• cultured dendritic cells lose nearly all of their matrix-degrading activity comapred to in wild-type cells
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growth/size/body
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• position of the incisor apex is anterior to that seen in controls and barely extends past the third molar at P20
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• starting at P18, observe a developmental delay of molars such that at P18, the molars have not yet erupted and the roots are underdeveloped
• by P23, the first two molars have erupted, however they are still covered by adherent debris that appears to be remnants of the overlying epithelium and by P25 this debris is mostly removed, however dentin and enamel appear normal
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• exhibit a developmental delay of approximately 5 days in tooth eruption
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