About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3652415
Allelic
Composition		 Fbn1tm3Rmz/Fbn1tm3Rmz
Fbn2tm1Rmz/Fbn2tm1Rmz
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3Rmz mutation (1 available); any Fbn1 mutation (171 available)
Fbn2tm1Rmz mutation (1 available); any Fbn2 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Fbn1tm3Rmz/Fbn1tm3Rmz Fbn2tm1Rmz/Fbn2tm1Rmz and Fbn1tm3Rmz/Fbn1+ Fbn2tm1Rmz/Fbn2tm1Rmz mice show poor organization of the aorta wall

mortality/aging

cardiovascular system
abnormal aorta tunica media morphology ( J:110586 )
• impaired or delayed elastogenesis in the medial layer of the aorta

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory