Phenotypes Associated with This Genotype

Genotype
MGI:3641455

• Allelic Composition: Sh2d1b2^tm1Vei/Sh2d1b2^tm1Vei
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:145969 )

• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)

• NK cell have inhibited killing of B16 melonama cells expressing CRACC

increased natural killer cell mediated cytotoxicity ( J:110195 )

• Il2-activated NK cells have an increased ability to kill target cells like YB cells in vitro

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:145969 )

• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)

• NK cell have inhibited killing of B16 melonama cells expressing CRACC

increased natural killer cell mediated cytotoxicity ( J:110195 )

• Il2-activated NK cells have an increased ability to kill target cells like YB cells in vitro