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Phenotypes Associated with This Genotype
Genotype
MGI:3641454
Allelic
Composition		 Sh2d1b1tm1Vei/Sh2d1b1tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1tm1Vei mutation (0 available); any Sh2d1b1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like CHO and YB cells in vitro
increased interferon-gamma secretion ( J:110195 )
• Il2-activated NK cells produce a 4- to 5-fold increase in receptor-mediated Ifng production in vitro

hematopoietic system
increased natural killer cell mediated cytotoxicity ( J:110195 )
• Il2-activated NK cells have an increased ability to kill target cells like CHO and YB cells in vitro

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory