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Phenotypes Associated with This Genotype
Genotype
MGI:3641451
Allelic
Composition		 Tg(CD2-Sh2d1b2)#Vei/0
Genetic
Background		 B6.Cg-Tg(CD2-Sh2d1b2)#Vei
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110195 )
• transgenic expression of Sh2d1b2 suppresses the ability of Il2-activated NK cells to kill target cells in vitro

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:110195 )
• transgenic expression of Sh2d1b2 suppresses the ability of Il2-activated NK cells to kill target cells in vitro

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory