Phenotypes Associated with This Genotype

Genotype
MGI:3641416

• Allelic Composition: Atoh7^tm1Gla/Atoh7^tm1Gla
• Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina cone cell morphology ( J:110600 )

• at E15.5 the number of RXRG -positive cones is increased and these cells are abnormally arranged

abnormal eye development ( J:110600 )

• retinal birthdating indicates an 80%, 70%, and 78% loss of E11.5 birthdated neurons in the ganglion cell, inner nuclear, and outer nuclear layers, respectively

• an 89% and 90% increase in the number of E13.5 and E15.5 birthdated outer nuclear layer neurons is also seen

• unlike in wild-type eyes E11.5 birthdated Muller glial cells are detected

• expression studies indicate that retinal cells are fail to become fully postmitotic from at least E11.5 to E14.5

cellular

abnormal cell cycle ( J:110600 )

• expression studies indicate that retinal cells are fail to become fully postmitotic from at least E11.5 to E14.5

• at E11.5 in the retina the number of G1/S phase, S phase, and M phase retinal progenitor cells is decreased by 48%, 20% and 37%, respectively, while at E14.5 the number of S phase cells is increased by 34%

nervous system

abnormal retina cone cell morphology ( J:110600 )

• at E15.5 the number of RXRG -positive cones is increased and these cells are abnormally arranged