Phenotypes for Atoh7 MGI:3641415 MGI Mouse

decreased retina rod cell number ( J:99410 )

• 28% fewer rods

abnormal retina bipolar cell morphology ( J:99410 )

• about 40% fewer Gnao1 positive cells

abnormal retina cone bipolar cell morphology ( J:99410 )

• about 60% fewer recoverin-positive cone OFF bipolar cells and these cells have shorter, more compact presynaptic arbors

abnormal retina rod bipolar cell morphology ( J:99410 )

• about 30% fewer protein kinase C positive rod bipolar cells and these cells have shorter axons

thin retina inner nuclear layer ( J:99410 )

• 45% thinner and the planimetric density is reduced by 38%

thin retina inner plexiform layer ( J:99410 )

• 40% thinner

thin retina outer nuclear layer ( J:99410 )

• 14% thinner and the planimetric density is reduced by 15%

thin retina outer plexiform layer ( J:99410 )

• 12% thinner

abnormal eye electrophysiology ( J:99410 )

• scotopic a- and b-wave and photopic b-wave amplitudes are decreased and a 30-fold brighter stimulus is needed for mutants to achieve the same amplitude as wild-type mice

• the scotopic b-wave is more severely affected than the a-wave

abnormal circardian behavior entrainment ( J:99410 )

• activity patterns do not photoentrain indicating the suprachiasmatic nuclei do not entrain; however free-running patterns are similar to wild-type

absent optic tract ( J:99410 )

• absent retinohypothalmic tract