Phenotypes Associated with This Genotype

Genotype
MGI:3641414

• Allelic Composition: Atoh7^tm1Gla/Atoh7^tm1Gla
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina cone cell number ( J:70746 )

• cone abundance is increased by about 75% and cells are found in clusters or ectopically in the outer segment layer

abnormal amacrine cell morphology ( J:70746 )

• A2 amacrines are decreased and dopaminergic amacrines appear to be absent; however the overall number of amacrine cells is similar to wild-type

abnormal retina ganglion layer morphology ( J:70746 )

• decreased cell number in layer resulting from absence of ganglion cells and axon bundles

• most or all of the cells in the remaining in the ganglion cell layer are amacrine cells

absent retina ganglion cell ( J:70746 )

• absence of ganglion cells and axon bundles

nervous system

absent retina ganglion cell ( J:70746 )

• absence of ganglion cells and axon bundles

increased retina cone cell number ( J:70746 )

• cone abundance is increased by about 75% and cells are found in clusters or ectopically in the outer segment layer

abnormal amacrine cell morphology ( J:70746 )

• A2 amacrines are decreased and dopaminergic amacrines appear to be absent; however the overall number of amacrine cells is similar to wild-type