Phenotypes Associated with This Genotype

Genotype
MGI:3640957

• Allelic Composition: Mos^tm1Gvw/Mos^tm1Gvw
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal primary polar body morphology ( J:34085 )

♀ • 20-30% of mutant oocytes extrude abnormally large polar bodies; half are >30 mm in diameter, while the remaining half undergo mitotic-like cleavage to produce cells of equal size

♀ • in 90% of mutant oocytes, the first polar body persists for more than 11 hrs while in wild-type it degrades by 7 hours

♀ • first polar bodies also elongate and frequently undergo an additional division instead of undergoing rapid degeneration

abnormal female meiosis ( J:34085 )

• the first meiotic division of mutant oocytes frequently resembles mitotic cleavage or produces an abnormally large polar body

parthenogenesis ( J:34085 )

• mutant oocytes fail to arrest at metaphase II and instead undergo parthenogenetic activation

abnormal meiotic spindle morphology ( J:34085 )

• the metaphase spindle does not properly translocate to the cell surface in mutant oocytes

reduced female fertility ( J:34085 )

♀ • mutant females exhibit reduced fertility

cellular

abnormal primary polar body morphology ( J:34085 )

♀ • 20-30% of mutant oocytes extrude abnormally large polar bodies; half are >30 mm in diameter, while the remaining half undergo mitotic-like cleavage to produce cells of equal size

♀ • in 90% of mutant oocytes, the first polar body persists for more than 11 hrs while in wild-type it degrades by 7 hours

♀ • first polar bodies also elongate and frequently undergo an additional division instead of undergoing rapid degeneration

abnormal female meiosis ( J:34085 )

• the first meiotic division of mutant oocytes frequently resembles mitotic cleavage or produces an abnormally large polar body

parthenogenesis ( J:34085 )

• mutant oocytes fail to arrest at metaphase II and instead undergo parthenogenetic activation

abnormal meiotic spindle morphology ( J:34085 )

• the metaphase spindle does not properly translocate to the cell surface in mutant oocytes