Phenotypes Associated with This Genotype

Genotype
MGI:3640796

• Allelic Composition: Ctnnd1^tm1Lfr/Ctnnd1^tm1Lfr
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:110469 )

• synaptic density is decreased in CA1 of mutant hippocampi

abnormal hippocampus pyramidal cell morphology ( J:110469 )

• linear dendritic spine density of pyramidal neurons is decreased to 39% that of wild-type controls

• spines appear smaller and shorter compared to controls

• in culture, hippocampal pyramidal neurons show ~40% decrease in dendritic branch points

• in mutants, spine length is ~ 66% less than control and spine head width is reduced by ~20% in cultured hippocampal neurons