Phenotypes Associated with This Genotype

Genotype
MGI:3640618

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:105327 )

obese ( J:106354 )

• exhibit mild obesity with an increase in body weight at 10 weeks of age that is 18.2% that of homozygous Lepr^tm1.2Chua mice

adipose tissue

increased total body fat amount ( J:105327 , J:106354 )

• increase in fat mass (J:105327)

• exhibit increased body fat but no differences in food intake or energy expenditure (J:106354)

abnormal fat pad morphology ( J:105327 , J:106354 )

abnormal epididymal fat pad morphology ( J:106354 )

• epididymal fat pads are at least twice as large as in controls

abnormal gonadal fat pad morphology ( J:105327 )

• size of perigonadal fat pads is increased

abnormal mesenteric fat pad morphology ( J:105327 , J:106354 )

• size of mesenteric fat pads is increased (J:105327)

• mesenteric fat pads are at least twice as large as in controls (J:106354)

abnormal renal fat pad morphology ( J:105327 , J:106354 )

• size of perirenal fat pads is increased (J:105327)

• perirenal fat pads are at least twice as large as in controls (J:106354)

homeostasis/metabolism

increased circulating leptin level ( J:105327 , J:106354 )