Phenotypes for H2 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi MGI:3640480 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^g7/H2^g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background	B6.Cg-H2^g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (23 available); any H2 mutation (304 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:86926 )

• animals show a significant reduction in overall diabetes incidence (14.6% vs ~50% in Tnfsf4-heterozygotes and wild-type) and increase in the age of onset (9.5 weeks vs 6 weeks in controls)

• mice are considered diabetic after a blood glucose measure of >300 mg/dl and 2 positive urine glucose tests

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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