Phenotypes Associated with This Genotype

Genotype
MGI:3640353

• Allelic Composition: Ggt1^tm1Zuk/Ggt1^tm1Zuk; Ggt5^tm1Mwl/Ggt5^tm1Mwl
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77691 )

• fail to thrive

• 70% die within 4 weeks of life

• lethality rescued if N-acetyl cysteine (NAC) provided in drinking water from birth but not if administration delayed until after weaning

• 84% of NAC treated mice survive to 28 days

• about 50% of NAC treated mice survive to 12 weeks

growth/size/body

postnatal growth retardation ( J:77691 )

• rescued by NAC administration in drinking water starting at birth

• weight of NAC treated mice at 8-12 weeks of age 90% of control weight

reproductive system

abnormal sexual maturation ( J:77691 )

• sexual immaturity

reduced fertility ( J:77691 )

• in NAC treated mice of both sexes when mated to wild-type partners

vision/eye

cataract ( J:77691 )

• NAC treatment partially prevents cataract formation

• bilateral

pigmentation

abnormal coat/hair pigmentation ( J:77691 )

• gray coat color

• more normal coat color in NAC treated mice

integument

abnormal coat/hair pigmentation ( J:77691 )

• gray coat color

• more normal coat color in NAC treated mice