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Phenotypes Associated with This Genotype
Genotype
MGI:3640343
Allelic
Composition
Fgfr3tm3.1Cxd/Fgfr3+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm3.1Cxd mutation (0 available); any Fgfr3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Smaller body size, dome-shaped heads and reduced bone density in Fgfr3tm3.1Cxd/Fgfr3tm3.1Cxd and Fgfr3tm3.1Cxd/Fgfr3+ mice

growth/size/body
• less affected than in homozyogtes
• less affected than in homozygotes

skeleton
• skulls are reduced in size along the anterior-posterior axis
• skulls are increased in size along the left-right and dorsal-ventral axes
• less affected than in homozyogtes
• exhibit an intermediate phenotype between wild-type and homozygous mutants, with some expansion of the resting zone and some reduction in the maturation and hypertrophic zones
• synchondrosis exhibit an intermediate phenotype between wild-type and homozygotes (thinner than wild-type) at P6

craniofacial
• skulls are reduced in size along the anterior-posterior axis
• skulls are increased in size along the left-right and dorsal-ventral axes
• less affected than in homozyogtes

limbs/digits/tail
• less affected than in homozyogtes

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondroplasia; ACH 100800 J:69849


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory