Mouse Genome Informatics
ht
    Fgfr3tm3.1Cxd/Fgfr3+
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Smaller body size, dome-shaped heads and reduced bone density in Fgfr3tm3.1Cxd/Fgfr3tm3.1Cxd and Fgfr3tm3.1Cxd/Fgfr3+ mice

growth/size/body
• less affected than in homozyogtes
• less affected than in homozygotes

skeleton
• skulls are reduced in size along the anterior-posterior axis
• skulls are increased in size along the left-right and dorsal-ventral axes
• less affected than in homozyogtes
• exhibit an intermediate phenotype between wild-type and homozygous mutants, with some expansion of the resting zone and some reduction in the maturation and hypertrophic zones
• synchondrosis exhibit an intermediate phenotype between wild-type and homozygotes (thinner than wild-type) at P6

craniofacial
• skulls are reduced in size along the anterior-posterior axis
• skulls are increased in size along the left-right and dorsal-ventral axes
• less affected than in homozyogtes

limbs/digits/tail
• less affected than in homozyogtes

Mouse Models of Human Disease
OMIM IDRef(s)
Achondroplasia; ACH 100800 J:69849