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Phenotypes Associated with This Genotype
Genotype
MGI:3640329
Allelic
Composition
Gnmttm1Cwa/Gnmttm1Cwa
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnmttm1Cwa mutation (1 available); any Gnmt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• free methionine are increased to 700 nmol/g liver and S-adenosylmethionine levels are increased to 1334 nmol/g liver compared to 100 and 37 nmol/g liver, respectively, in wild-type mice (J:110257)
• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is increased about 100 fold (J:110257)
• free methionine are increased to 700 nmol/g liver and S-adenosylmethionine levels are increased to 1334 nmol/g liver compared to 100 and 37 nmol/g liver, respectively, in wild-type mice (J:110257)
• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is increased about 100 fold (J:110257)

Mouse Models of Human Disease
OMIM ID Ref(s)
Glycine N-Methyltransferase Deficiency 606664 J:110257


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory