Phenotypes Associated with This Genotype

Genotype
MGI:3640310

• Allelic Composition: Csn3^tm1Kuma/Csn3^tm1Kuma
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal milk composition ( J:110223 )

♀ • mammary gland morphology is normal but protein aggregates are found in the alveolar lumina, these appear to be the result of coagulation and retention of secreted caseins

lactation failure ( J:110223 )

♀ • failure of lactation; however, both sexes are fertile and females can carry pups to term

♀ • when injected with oxytocin females produce no milk but do produce very small volumes of a yellowish secretion

integument

abnormal milk composition ( J:110223 )

♀ • mammary gland morphology is normal but protein aggregates are found in the alveolar lumina, these appear to be the result of coagulation and retention of secreted caseins

lactation failure ( J:110223 )

♀ • failure of lactation; however, both sexes are fertile and females can carry pups to term

♀ • when injected with oxytocin females produce no milk but do produce very small volumes of a yellowish secretion