Phenotypes for Fyn MGI:3640282 MGI Mouse

decreased corpus callosum size ( J:109485 )

• thickness of corpus callosum is reduced compared to wild-type

abnormal hippocampus morphology ( J:80637 )

abnormal dentate gyrus morphology ( J:80637 )

• abnormal arrangement of rostral dentate gyrus

abnormal hippocampus pyramidal cell layer ( J:80637 )

• CA1 pyramidal cells are less tightly packed

• caudal CA3 pyramidal cell regions shows an abnormal arrangement

abnormal hippocampus pyramidal cell morphology ( J:80637 )

• dendritic regions of pyramidal cells are narrow and length of the apical dendrites is shortened

ectopic hippocampus pyramidal cells ( J:80637 )

• ectopic pyramidal cells are frequently seen

abnormal optic nerve morphology ( J:109485 )

• there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type

abnormal myelination ( J:109485 )

• in the forebrain from P14 to P385, a myelin deficit is observed; at P26, deficit is 52% compared to controls

• myelin basic protein content in the brain is significantly reduced with a magnitude of 40%

reduced long-term potentiation ( J:80637 )

• exhibit age-dependent impairment of LTP that appears only when homozygotes are over 10 weeks of age

abnormal optic nerve morphology ( J:109485 )

• there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type

reproductive system phenotype ( J:185783 )

N	• despite their reduced epididymal size and sperm count, male mice produce normal litter sizes when mated with wild-type females and are technically fertile

abnormal sperm motility ( J:185783 )

• in vitro, cauda epididymal sperm show small but significant reductions in total, progressive, and hyperactive motility and increased local (twitching, nonprogressive) motility before capacitation

• after capacitation, sperm show normal total and hyperactive motility, a slight increase in progressive motility, and a small reduction in local motility, suggesting that differences in motility parameters are relatively minor

abnormal spermatogenesis ( J:185783 )

• later stages of spermatogenesis are negatively impacted

oligozoospermia ( J:185783 )

• at 7-8 weeks of age, epididymal sperm count is significantly lower than that in wild-type males

teratozoospermia ( J:185783 )

• males show a high frequency of morphological defects in cauda epididymal sperm

abnormal sperm connecting piece morphology ( J:185783 )

• incorrect head-to-neck connections are commonly observed

abnormal sperm head morphology ( J:185783 )

• club-shaped and triangular head morphologies and incorrect head-to-neck connections are commonly observed

abnormal spermiogenesis ( J:185783 )

• abnormal sperm head structures are observed during spermiogenesis

abnormal sperm capacitation ( J:185783 )

• in vitro capacitated sperm show slight alterations in the pattern of capacitation-induced protein tyrosine phosphorylation, with decreased abundance of several minor phosphoproteins

decreased epididymis weight ( J:185783 )

• at 7-8 weeks of age, epididymal weight is significantly lower than that in wild-type males

• however, testis weight is normal

impaired acrosome reaction ( J:185783 )

• following in vitro capacitation, the rate of A23187-induced acrosome reaction in cauda epididymal sperm is significantly lower than that in wild-type sperm

• however, in the absence of induction, sperm show the same low frequency of spontaneous acrosome reactions as wild-type sperm

decreased fertilization frequency ( J:185783 )

• an in vivo competitive artificial insemination trial showed that the average % of embryos produced per female by mutant epididymal sperm is about one-sixth of that produced by wild-type sperm (14.4% versus 85.6%), indicating impaired sperm fertilizing capacity

impaired sperm penetration of zona pellucida ( J:185783 )

• in an IVF assay, sperm show a significantly reduced ability to penetrate the zona pellucida than wild-type sperm, resulting in a lower frequency of sperm retained in the perivitelline space or fused with the ooplasm