Phenotypes Associated with This Genotype

Genotype
MGI:3640191

• Allelic Composition: Reln^rl/Reln^rl
• Genetic Background: B6.Cg-Reln^rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:5312 )

• Background Sensitivity: all die by 30 days of age, earlier than on a C3H/HeJ background

behavior/neurological

impaired righting response ( J:5312 )

• Background Sensitivity: if turned on the side, mutants on a C57BL/6J background kick all legs futilely in unison and may not be able to right themselves without assistance, a phenotype not seen on the C3H/HeJ background

tremors ( J:5312 )

• Background Sensitivity: mice show rapid unsustained low amplitude tremor of the body when walking starting at P13 that is not readily observed on a C3H/HeJ background

ataxia ( J:5312 )

• Background Sensitivity: mice show ataxic gait beginning at P13 that is more severe than on a C3H/HeJ background

abnormal gait ( J:5312 )

• hind legs tend to splay and mice frequently fall on their sides

decreased locomotor activity ( J:5312 )

• Background Sensitivity: general level of activity begins to decrease during the third week of life unlike on a C3H/HeJ background in which activity is normal

growth/size/body

decreased body weight ( J:5312 )

• Background Sensitivity: mice attain maximum weight by the end of the second week of life, then growth ceases during the third week and mutants remain smaller thereafter

postnatal growth retardation ( J:5312 )

• Background Sensitivity: growth retardation is more severe than on a C3H/HeJ background

reproductive system

infertility ( J:5312 )

• Background Sensitivity: mutants with a C57BL/6J background do not live long enough to breed while those with a C3H/HeJ background may be fertile

nervous system

abnormal entorhinal cortex morphology ( J:5312 )

• the entorhinal cortex exhibits an outer zone of tangentially oriented polymorphic cells in the superficial plane normally given to an external plexiform layer

• a wide inner zone of larger cells in the entorhinal cortex is cytologically similar to the outer large cell layers of the normal

abnormal hippocampus morphology ( J:5312 )

abnormal hippocampus CA1 region morphology ( J:5312 )

• CA1 has two separate cellular laminae

abnormal hippocampus CA2 region morphology ( J:5312 )

• CA2 is subluxed away from its junction with CA1

abnormal dentate gyrus morphology ( J:5312 )

• many granule cells of the dentate gyrus are scattered through the hilus and are intermixed with large cells of CA4

abnormal olfactory cortex morphology ( J:5312 )

• the piriform cortex is composed of an outer polymorphic and inner large cell zone, resembling the deep polymorphic and overlying pyramidal zones of wild-type

• immediately subjacent to the lateral olfactory tract, the outer polymorphic zone is attenuated

abnormal sensory neuron innervation pattern ( J:5312 )

• fiber bundles course from the olfactory crus in aberrant superficial relation to the lateral olfactory tract and join the main mass of the anterior commissure at a more caudal level