Analysis Tools
mortality/aging
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• Background Sensitivity: 80% die by 40 days of age, the rest survive and are in normal health, indicating increased vitality than on a C57BL/6J background
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behavior/neurological
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• Background Sensitivity: mutants on a C57BL/6J background crossed to C3H/HeJ to the N7 generation only show mild behavioral/neurological disabilities compared to mutants on a C57BL/6J background, and are able to right themselves and remain active
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• Background Sensitivity: at around 4 weeks of age, develop a more moderate ataxia during ambulation than on a C57BL/6J background
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growth/size/body
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• Background Sensitivity: growth retardation is much less severe than on a C57BL/6J background
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• Background Sensitivity: exhibit normal weight gain during the first 2 weeks of life, then growth decreases in the third week but weight gain resumes after weaning, although at a slower rate so that by 60 days, they are still growing but weight is less than 70% of wild-type
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digestive/alimentary system
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• more than half of the mutants lost during the 20- to 30-day interval die as a consequence of diarrhea
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nervous system
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• different classes of neurons take their orgin from the ependymal layer at the normal time but migrate abnormally and come to rest in abnormal relations to each other
• migratory ascent along the radial glial fibers (RGF) proceeds normally as the cell crosses the IZ but is blocked upon encounter with postmigratory neurons within the cortex
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• the entorhinal cortex exhibits an outer zone of tangentially oriented polymorphic cells in the superficial plane normally given to an external plexiform layer
• a wide inner zone of larger cells in the entorhinal cortex is cytologically similar to the outer large cell layers of the normal
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• CA1 has two separate cellular laminae
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• CA2 is subluxed away from its junction with CA1
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• many granule cells of the dentate gyrus are scattered through the hilus and are intermixed with large cells of CA4
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• the ascending glial fiber gives rise to 3 or less terminal branches (compared to 3-5 or more in wild-type) within the superplate (SP) rather than the pleriform zone (PZ)
• at the lower margin of the cortex, cells are frequently found bunched close one upon the other with substantial overlap of radially adjacent cells and the leading processes of these cells are abnormally short and blunt
• extent of contact between the somatic surfaces of postmigratory neurons and the surfaces of the radial glial fibers is substantially greater than in wild-type indicating abnormal adhesions between the postmigratory cells and the radial glial fibers
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• the piriform cortex is composed of an outer polymorphic and inner large cell zone, resembling the deep polymorphic and overlying pyramidal zones of wild-type
• immediately subjacent to the lateral olfactory tract, the outer polymorphic zone is attenuated
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• fiber bundles course from the olfactory crus in aberrant superficial relation to the lateral olfactory tract and join the main mass of the anterior commissure at a more caudal level
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cellular
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• different classes of neurons take their orgin from the ependymal layer at the normal time but migrate abnormally and come to rest in abnormal relations to each other
• migratory ascent along the radial glial fibers (RGF) proceeds normally as the cell crosses the IZ but is blocked upon encounter with postmigratory neurons within the cortex
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