Phenotypes Associated with This Genotype

Genotype
MGI:3640175

• Allelic Composition: Gabra2^tm1.1Dias/Gabra2^tm1.1Dias
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:109259 )

N • nonselective benzodiazepines including TP003 as well as the chlordiazepoxide retained normal efficacy in a stress-induced hyperthermia model

behavior/neurological

impaired behavioral response to xenobiotic ( J:108919 )

• resistant to the anxiolytic effects of diazepam in a model of conditioned anxiety; however, a compound, L-838417 gave rise to anxiolytic-like activity in mutant mice