Phenotypes Associated with This Genotype

Genotype
MGI:3639895

• Allelic Composition: Sod2^tm1Cje/Sod2^tm1Cje
• Genetic Background: D2.Cg-Sod2^tm1Cje

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:73998 )

• mean life span is 8.7 +/- 0.3 days

• Background Sensitivity: mean life span is longer than on a congenic C57BL/6J background but shorter than on a hybrid C57BL/6J DBA/2J background

cardiovascular system

increased heart weight ( J:73998 )

• heart weight to body weight ratios are progressively increased with age and show mild hypertrophy but no myocardial inflammation or fibrosis

• Background Sensitivity: no dilated cardiomyopathy is seen unlike mice on a congenic C57BL/6J or CD-1 background

cardiac hypertrophy ( J:73998 )

• mild

homeostasis/metabolism

abnormal blood homeostasis ( J:73998 )

abnormal blood gas level ( J:73998 )

• increase in pO2 and decrease in pCO2 suggest a compensatory increase in respiration as a result of metabolic acidosis

• Background Sensitivity: changes in pO2 and pCO2 are smaller than in mice on a hybrid C57BL/6J DBA/2J background

increased blood urea nitrogen level ( J:73998 )

• Background Sensitivity: seen earlier in congenic mice than in mice on a hybrid C57BL/6J and DBA/2J background

decreased circulating glucose level ( J:73998 )

• Background Sensitivity: seen earlier in congenic mice than in mice on a hybrid C57BL/6J and DBA/2J background

increased circulating ketone body level ( J:73998 )

• Background Sensitivity: higher levels and seen earlier than in homozygotes on a hybrid C57BL/6J and DBA/2J background

abnormal enzyme/coenzyme level ( J:73998 )

• Background Sensitivity: at P5, heart levels of SOD1 activity are increased unlike mice on a hybrid C57BL/6J DBA/2J background where SOD1 activity is also increased in the brain, liver, and lung

increased circulating alkaline phosphatase level ( J:73998 )

• seen in some older mice

increased circulating aspartate transaminase level ( J:73998 )

• seen in some older mice

hypocapnia ( J:73998 )

• a 24% decrease in pCO2 is seen

• Background Sensitivity: decrease is smaller than in mice on a hybrid C57BL/6J and DBA/2J background

hyperoxia ( J:73998 )

• a 20% increase in pO2 is seen

• Background Sensitivity: increase is smaller than in mice on a hybrid C57BL/6J and DBA/2J background

metabolic acidosis ( J:73998 )

• severe metabolic acidosis

• by P5 a rapid decline in HCO3 levels and blood pH is seen

abnormal urine homeostasis ( J:73998 )

• at P5 urinary organic acid levels are elevated

liver/biliary system

hepatic steatosis ( J:73998 )

• Background Sensitivity: large amounts of fat in the liver compared to wild-type or homozygotes on a hybrid C57BL/6J and DBA/2J background

cellular

abnormal mitochondrial physiology ( J:73998 )

• mithochondrial but not cytoplasmice aconitase activity is reduced in the brain, heart, lung, liver, kidney, and skeletal muscle

renal/urinary system

abnormal urine homeostasis ( J:73998 )

• at P5 urinary organic acid levels are elevated

growth/size/body

increased heart weight ( J:73998 )

• heart weight to body weight ratios are progressively increased with age and show mild hypertrophy but no myocardial inflammation or fibrosis

• Background Sensitivity: no dilated cardiomyopathy is seen unlike mice on a congenic C57BL/6J or CD-1 background

cardiac hypertrophy ( J:73998 )

• mild

decreased body weight ( J:73998 )