Phenotypes Associated with This Genotype

Genotype
MGI:3639894

• Allelic Composition: Sod2^tm1Cje/Sod2⁺
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased hepatocyte apoptosis ( J:67874 )

• increased 3-fold at 20 - 25 months of age

abnormal mitochondrial physiology ( J:67874 )

• liver mitochondria are more prone to permeability transition following calcium addition

• liver mitochondrial membrane electrochemical potential is lower than in wild-type

• liver mitochondrial oxidative phosphorylation complexes I, II, II + III, and IV and citrate synthase are elevated 25% - 75% in 20 to 25 month old mice

abnormal respiratory electron transport chain ( J:67874 )

• state III respiratory rate is reduced in liver cells at 5 and 10 - 14 months of age, but by 20 - 25 months control rates decrease so that they are similar to homozygotes

• state IV respiration rate is increased in 10 - 14 and 20 - 25 month old mice but not in young (5 month old) mice

• state III respiratory control ratios are reduced in young and middle aged mice but closer to normal in old mice

oxidative stress ( J:67874 )

• at 10 - 14 months of age, liver mitochondria contain twice as much lipid hydroperoxides as in controls, but lipid peroxide levels decrease in old homozygotes

liver/biliary system

increased hepatocyte apoptosis ( J:67874 )

• increased 3-fold at 20 - 25 months of age