Phenotypes Associated with This Genotype

Genotype
MGI:3639893

• Allelic Composition: Sod2^tm1Cje/Sod2^tm1Cje
• Genetic Background: B6.Cg-Sod2^tm1Cje/Mmmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:73998 )

• mean life span is 0.9 +/- 0.3 days

• at E19 when delivered by cesarean section only 11.6% are homozygous and after natural birth only 8.4% are homozygous

• Background Sensitivity: mean life span is reduced compared to mice on a congenic DBA2/J or hybrid C57BL/6J and DBA2/J background

lethality throughout fetal growth and development, incomplete penetrance ( J:73998 )

• at E15, 4 of 19 fetuses are dead

cardiovascular system

enlarged heart ( J:73998 )

• at E15, moderate to massive enlargement is seen

dilated heart left ventricle ( J:73998 )

• dilated left and right ventricles are seen in severe cases

thin ventricular wall ( J:73998 )

• seen with dilated ventricles in severe cases

dilated heart right ventricle ( J:73998 )

• dilated left and right ventricles are seen in severe cases

dilated cardiomyopathy ( J:73998 )

• at E15, moderate to massive enlargement with the largest hearts having dilated left and right ventricular cavities with thinner muscular walls

• Background Sensitivity: dilated cardiomyopathy is seen on a congenic C57BL/6J background but not in mice on congenic DBA/2J or hybrid C57BL/6J and DBA/2J backgrounds

growth/size/body

enlarged heart ( J:73998 )

• at E15, moderate to massive enlargement is seen

decreased fetal size ( J:73998 )

• at E15, surviving mice are 21% smaller than age-matched wild-type littermates

cellular

oxidative stress ( J:108637 )

• increased cardiomyocyte apoptosis after treatment with t-BuOOH to induce oxidative stress

muscle

dilated cardiomyopathy ( J:73998 )

• at E15, moderate to massive enlargement with the largest hearts having dilated left and right ventricular cavities with thinner muscular walls

• Background Sensitivity: dilated cardiomyopathy is seen on a congenic C57BL/6J background but not in mice on congenic DBA/2J or hybrid C57BL/6J and DBA/2J backgrounds