Phenotypes Associated with This Genotype

Genotype
MGI:3639857

• Allelic Composition: Neurog2^tm1Fgu/Neurog2^tm1Fgu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:46667 )

• most mutants die during the first postnatal day

postnatal lethality, complete penetrance ( J:46667 )

• mutants surviving past the first day die between 4 and 25 days of age

growth/size/body

decreased body size ( J:46667 )

• homozygotes are smaller in size than littermates

postnatal growth retardation ( J:46667 )

• mutants surviving past the first day exhibit progressive growth retardation until time of death

behavior/neurological

abnormal suckling behavior ( J:46667 )

• mutants are unable to feed normally, as their stomachs lacked milk and were filled with air

abnormal limb posture ( J:46667 )

• mutants exhibit abnormal limb posturing

decreased locomotor activity ( J:46667 )

• mutants exhibit a low level of activity after birth

• surviving mutants exhibit decreased motor activity with time until death between 4 and 25 days of age

nervous system

abnormal autonomic nervous system morphology ( J:157532 )

abnormal parasympathetic ganglion morphology ( J:157532 )

• at 13.5 all parasympathetic ganglia of the head are missing

abnormal motor neuron morphology ( J:157532 )

• visceromotor neurons project abnormally in the facial nerve

abnormal dorsal interneuron morphology ( J:98830 )

• in E10.5 embryos a subtle increase in the number of dI3 and dI5 neurons is seen

• but, no significant changes in the number of dI2 and dI4/6 neurons is detected

abnormal somatic nervous system morphology ( J:157532 )

abnormal geniculate ganglion morphology ( J:46667 )

• neuronal differentiation is absent or abnormal in this ganglion

abnormal petrosal ganglion morphology ( J:46667 )

• neuronal differentiation is absent or abnormal in this ganglion

abnormal facial nerve morphology ( J:157532 )

• neither the corda tympani nor the greater superficial petrosal nerve have formed at E11.5

abnormal dorsal root ganglion morphology ( J:74525 )

• mice show a transient defect in neurogenesis in populations of sensory neurons in the DRGs