Phenotypes Associated with This Genotype

Genotype
MGI:3639779

• Allelic Composition: Gphn^tm1Jrs/Gphn^tm1Jrs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77775 )

• born in expected numbers

• all die within 1 day of birth

behavior/neurological

abnormal suckling behavior ( J:77775 )

• fail to suckle

abnormal posture ( J:77775 )

• become rigid and hyperextended in response to tactile stimulus

hyperresponsive ( J:77775 )

• to tactile stimulus

abnormal vocalization ( J:77775 )

• no normal vocalizations

respiratory system

apnea ( J:77775 )

• by 12 hours of age

nervous system

abnormal motor neuron morphology ( J:77775 )

• failure of glycine receptors to localize at inhibitory motoneuron synapses