Phenotypes Associated with This Genotype

Genotype
MGI:3639764

• Allelic Composition: Ascl1^{tm1(Neurog2)Fgu}/Ascl1^{tm1(Neurog2)Fgu}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:74525 )

• homozygotes die at birth

nervous system

abnormal neuron apoptosis ( J:109482 )

• at E11.5 and E12.5, numbers of TUNEL positive cells in the spinal cords of mutants are significantly increased over wild-type in the ventricular zone

abnormal locus ceruleus morphology ( J:74525 )

• structure is absent in mutants at E13.5 and PO

abnormal dorsal interneuron LA morphology ( J:109482 )

• expression of Ngn2 is unable to rescue the deficits in dILA interneurons observed in Ascl1^tm1And homozygotes

abnormal ventral interneuron 2 morphology ( J:74525 )

• V2 interneuron numbers are reduced to a similar extent as Ascl1^tm1And

cellular

abnormal neuron apoptosis ( J:109482 )

• at E11.5 and E12.5, numbers of TUNEL positive cells in the spinal cords of mutants are significantly increased over wild-type in the ventricular zone