Phenotypes Associated with This Genotype

Genotype
MGI:3639731

• Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:109475 )

• severely affected mutants (35%) die by E10; most (65%) survive to birth

embryo

small pharyngeal arch ( J:109475 )

• at E8.75 -10.5, surviving mutants have small pharyngeal arches

cellular

increased apoptosis ( J:109475 )

• excess apoptotic cells are detected at the 7-9 somite stage in ventral endoderm and adjacent smooth muscle

cardiovascular system

abnormal truncus arteriosus septation ( J:109475 )

• conotruncal cushions are hypocellular compared to controls; fusion of cushions to form AP septum is delayed in mutants

persistent truncus arteriosus ( J:109475 )

• 100% of E18.5/newborns have PTA

abnormal heart right ventricle morphology ( J:109475 )

• at E8.75 -10.5, surviving mutants have severe right ventricle hypoplasia

craniofacial

small pharyngeal arch ( J:109475 )

• at E8.75 -10.5, surviving mutants have small pharyngeal arches