Phenotypes Associated with This Genotype

Genotype
MGI:3639730

• Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:109475 )

• severely affected Fgf8-deficient embryos (65%) die by E10

homeostasis/metabolism

pericardial effusion ( J:109475 )

• embryos die by E10 with pericardial effusion in 65% of embryos

edema ( J:109475 )

• embryos die by E10 with generalized edema in 65% of embryos

cardiovascular system

abnormal cardiac outflow tract development ( J:109475 )

• OFTs are short or absent in 65% of embryos

abnormal heart tube morphology ( J:109475 )

• heart tube is hypoplastic in 65% of embryos

transposition of great arteries ( J:109475 )

• 30% of the embryos born show transposition of the great arteries

common atrium ( J:109475 )

• there is a single dilated atrium in 65% of embryos

common ventricle ( J:109475 )

• there is a single dilated ventricle in 65% of embryos

bicuspid aortic valve ( J:109475 )

• 40% of newborns also have a bicuspid aortic valve

bicuspid pulmonary valve ( J:109475 )

• 40% of newborns also have a bicuspid pulmonary valve

decreased heart right ventricle size ( J:109475 )

• 35% of embryos survive but have small right ventricles at midgestation

pericardial effusion ( J:109475 )

• embryos die by E10 with pericardial effusion in 65% of embryos

cellular

increased apoptosis ( J:109475 )

• excess apoptotic cells are detected at the 7-9 somite stage in ventral endoderm and adjacent smooth muscle

decreased cell proliferation ( J:109475 )

• at the 4 somite stage, mutants have 46% fewer proliferating cells in crescent mesoderm; this persisted to the 9 somite stage

• proliferating cells are decreased in the proximal outflow tract and pharyngeal epithelium at the 9 somite stage