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Phenotypes Associated with This Genotype
Genotype
MGI:3639722
Allelic
Composition		 Wnt1tm1Brd/Wnt1tm1Brd
Wnt4tm1Amc/Wnt4tm1Amc
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt1tm1Brd mutation (0 available); any Wnt1 mutation (29 available)
Wnt4tm1Amc mutation (2 available); any Wnt4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:75999 )
• at E15-E16, double homozygotes show a 50-70% reduction of immature and mature thymocytes relative to wild-type embryos; this decrease is significantly greater than that observed in either single homozygote (20-30%)

immune system
decreased thymocyte number ( J:75999 )
• at E15-E16, double homozygotes show a 50-70% reduction of immature and mature thymocytes relative to wild-type embryos; this decrease is significantly greater than that observed in either single homozygote (20-30%)

endocrine/exocrine glands
decreased thymocyte number ( J:75999 )
• at E15-E16, double homozygotes show a 50-70% reduction of immature and mature thymocytes relative to wild-type embryos; this decrease is significantly greater than that observed in either single homozygote (20-30%)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory