Phenotypes Associated with This Genotype

Genotype
MGI:3639669

• Allelic Composition: Dnase1^tm1Tmo/Dnase1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:62549 )

• some heterozygotes display symptoms of systemic lupus erythematosus at 6-8 months of age and die

immune system

enlarged spleen ( J:62549 )

• 10/66 heterozygotes exhibi splenomegaly

increased anti-nuclear antigen antibody level ( J:62549 )

• mice show anti-nuclear antibodies

• 48% of male mice and 65% of female mice display anti-nuclear antibodies compared to 15% of male and 35% of wild-type mice

kidney inflammation ( J:62549 )

• 24/66 show perivascular leukocytic infiltration in the kidney

glomerulonephritis ( J:62549 )

• in males, 15% show glomerulonephritis compared to 0% of wild-type; 19% of female heterozygotes show glomerulonephritis compared to 12% in wild-type

hematopoietic system

enlarged spleen ( J:62549 )

• 10/66 heterozygotes exhibi splenomegaly

renal/urinary system

kidney inflammation ( J:62549 )

• 24/66 show perivascular leukocytic infiltration in the kidney

glomerulonephritis ( J:62549 )

• in males, 15% show glomerulonephritis compared to 0% of wild-type; 19% of female heterozygotes show glomerulonephritis compared to 12% in wild-type

growth/size/body

enlarged spleen ( J:62549 )

• 10/66 heterozygotes exhibi splenomegaly