Phenotypes for Cdk2 Cdk4 Cdkn1b MGI:3639610 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdk2^tm1Kald/Cdk2^tm1Kald Cdk4^tm1Kiyo/Cdk4^tm1Kiyo Cdkn1b^tm1Ako/Cdkn1b^tm1Ako
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Kald mutation (0 available); any Cdk2 mutation (16 available)
Cdk4^tm1Kiyo mutation (0 available); any Cdk4 mutation (57 available)
Cdkn1b^tm1Ako mutation (0 available); any Cdkn1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:108720 )

• embryos appear normal at E13.5 and die around E15.5

cellular

decreased cell proliferation ( J:108720 )

• MEFs show decreased proliferation rate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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