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Phenotypes Associated with This Genotype
Genotype
MGI:3639610
Allelic
Composition		 Cdk2tm1Kald/Cdk2tm1Kald
Cdk4tm1Kiyo/Cdk4tm1Kiyo
Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Kald mutation (0 available); any Cdk2 mutation (16 available)
Cdk4tm1Kiyo mutation (0 available); any Cdk4 mutation (57 available)
Cdkn1btm1Ako mutation (0 available); any Cdkn1b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:108720 )
• embryos appear normal at E13.5 and die around E15.5

cellular
decreased cell proliferation ( J:108720 )
• MEFs show decreased proliferation rate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory