Analysis Tools
cardiovascular system
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• at the time of death, heart weight relative to body weight is increased; degree of cardiomegaly is less than in transgenic lines M13 and O7
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• modest increase in left ventricular mass reaching significance at 5 weeks of age
• develop a concentric form of left ventricular hypertrophy, maintain near normal systolic function in the first 2 months of life, and subsequently develop heart failure
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• wall thickness is increased at 3 weeks of age and remains increased
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• exhibit preserved systolic function except at 5 weeks when fractional shortening is slightly but significantly decreased
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• 4 month old mutants exhibit decreased left-ventricular systolic function
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• develop a concentric form of left ventricular hypertrophy, maintain near normal systolic function in the first 2 months of life, and subsequently develop heart failure
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muscle
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• modest increase in left ventricular mass reaching significance at 5 weeks of age
• develop a concentric form of left ventricular hypertrophy, maintain near normal systolic function in the first 2 months of life, and subsequently develop heart failure
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• exhibit preserved systolic function except at 5 weeks when fractional shortening is slightly but significantly decreased
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growth/size/body
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• at the time of death, heart weight relative to body weight is increased; degree of cardiomegaly is less than in transgenic lines M13 and O7
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• modest increase in left ventricular mass reaching significance at 5 weeks of age
• develop a concentric form of left ventricular hypertrophy, maintain near normal systolic function in the first 2 months of life, and subsequently develop heart failure
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