Mouse Genome Informatics
hm
    Mc3rtm1Cone/Mc3rtm1Cone
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• on a low-fat chow, mutants show increased fat content without gross weight being different
• female null mice are significantly heavier than wild-type around 50-60 days of age
• mutants are obese with the proportion of fat increasing by ~40% around 15-20 weeks of age compared to wild-type (31.8% in wild-type vs 45.2% in Mc3r-null mice)

homeostasis/metabolism
• mice show a trend toward greater oxygen consumption on low or high fat diets compared to wild-type
• when switched to high fat chow, mutants show a dramatic increase in respiratory quotient 24 hours after the switch
• mutants show a reduced RQ compared to wild-type on a low fat chow diet and a higher RQ on high fat chow

behavior/neurological
• despite increased body fat, mice do not exhibit weight gain or increased food consumption

adipose tissue
• on a low-fat chow, mutants show increased fat content without gross weight being different

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:78132