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Phenotypes Associated with This Genotype
Genotype
MGI:3639354
Allelic
Composition
Mc3rtm1Cone/Mc3rtm1Cone
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc3rtm1Cone mutation (1 available); any Mc3r mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• female null mice are significantly heavier than wild-type around 50-60 days of age
• mutants are obese with the proportion of fat increasing by ~40% around 15-20 weeks of age compared to wild-type (31.8% in wild-type vs 45.2% in Mc3r-null mice)

homeostasis/metabolism
• mice show a trend toward greater oxygen consumption on low or high fat diets compared to wild-type
• when switched to high fat chow, mutants show a dramatic increase in respiratory quotient 24 hours after the switch
• mutants show a reduced RQ compared to wild-type on a low fat chow diet and a higher RQ on high fat chow

behavior/neurological
• despite increased body fat, mice do not exhibit weight gain or increased food consumption

adipose tissue
• on a low-fat chow, mutants show increased fat content without gross weight being different

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:78132


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory