Phenotypes Associated with This Genotype

Genotype
MGI:3639329

• Allelic Composition: Camp^tm1Rlg/Camp^tm1Rlg
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:199719 )

• in the cornea of mice infected with F. solani

increased incidence of corneal inflammation ( J:199719 )

• in mice infected with F. solani

increased susceptibility to bacterial infection ( J:72924 )

• homozygotes are more susceptible to Group A Streptococcus infection, developing larger areas of infection and showing a more rapid increase in lesion areas and longer persistence of lesions

increased susceptibility to fungal infection ( J:199719 )

• mice infected with F. solani exhibit more rapid development of keratitis (cornea cloudiness and edema), increased neutrophil infiltration (determined by MPO activity and plate count) and enhanced fungal load without recovery compared with wild-type mice

vision/eye

increased incidence of corneal inflammation ( J:199719 )

• in mice infected with F. solani

hematopoietic system

increased neutrophil cell number ( J:199719 )

• in the cornea of mice infected with F. solani