Phenotypes Associated with This Genotype

Genotype
MGI:3639298

• Allelic Composition: Snx1^tm1Mag/Snx1^tm1Mag; Snx2^tm1Mag/Snx2^tm1Mag
• Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:103556 )

• embryos typically arrest and die between E9.5 and E11.5

growth/size/body

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

embryo

abnormal embryo turning ( J:103556 )

• in most cases, do not undergo axial rotation

caudal body truncation ( J:103556 )

• exhibit a truncated posterior at E9.5

embryonic growth arrest ( J:103556 )

• embryos typically arrest between E9.5 and E11.5

decreased embryo size ( J:103556 )

• embryos are retarded in growth by E7.5

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5

abnormal extraembryonic tissue morphology ( J:103556 )

• by E8.5, exhibit disproportionate growth of the extraembryonic structures compared with embryonic ectoderm, resulting in a large yolk sac and allantois compared to embryo size

abnormal visceral yolk sac morphology ( J:103556 )

• overgrowth of the yolk sac is seen at E8.5

abnormal visceral yolk sac endoderm morphology ( J:103556 )

• exhibit an increased prevalence of apical electron dense structures in the yolk sac visceral endoderm

abnormal chorioallantoic fusion ( J:103556 )

• variability in chorioallantoic fusion

nervous system

incomplete rostral neuropore closure ( J:103556 )

• neural folds are not fused at E9.5