Phenotypes Associated with This Genotype

Genotype
MGI:3639283

• Allelic Composition: Tg(Myh6-Prkaa2*D157A)1Rti/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:86014 )

• mutants exhibit normal cardiac morphology and physiology under normal conditions, however when subjected to ischemia, hearts show more rapid increase in left ventricular end-diastolic pressure, accelerated rate and extent of ATP depletion (increased ATP degradation), and a decrease in glucose uptake

homeostasis/metabolism

abnormal response to cardiac infarction ( J:86014 )

• mutants exhibit normal cardiac morphology and physiology under normal conditions, however when subjected to ischemia, hearts show more rapid increase in left ventricular end-diastolic pressure, accelerated rate and extent of ATP depletion (increased ATP degradation), and a decrease in glucose uptake