Phenotypes Associated with This Genotype

Genotype
MGI:3639142

• Allelic Composition: Tg(Myh6-Akt1)20Anr/Y
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:77257 )

♂ • the heart weight/body weight ratio is 1.7-fold greater than in wild-type male littermates

heart left ventricle hypertrophy ( J:77257 )

♂ • exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal

thick ventricular wall ( J:77257 )

♂ • increase in left ventricular wall thickness

decreased myocardial infarct size ( J:77257 )

♂ • infarct size after coronary ligation is reduced by about 50% compared with controls

homeostasis/metabolism

decreased myocardial infarct size ( J:77257 )

♂ • infarct size after coronary ligation is reduced by about 50% compared with controls

growth/size/body

cardiac hypertrophy ( J:77257 )

♂ • the heart weight/body weight ratio is 1.7-fold greater than in wild-type male littermates

heart left ventricle hypertrophy ( J:77257 )

♂ • exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal

muscle

heart left ventricle hypertrophy ( J:77257 )

♂ • exhibit left ventricle hypertrophy that is slightly more marked in males than females, however systolic ventricular function is normal