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Phenotypes Associated with This Genotype
Genotype
MGI:3639140
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (13 available); any H2-Ab1 mutation (81 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:68641 )
• only one of the MHC class II-deficient mice developed diabetes (blood glucose >250 mg/dl)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory