Phenotypes Associated with This Genotype

Genotype
MGI:3639135

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru; Tg(HLA-DQA1,HLA-DQB1)1Dv/0; Tg(Ins2-CD80)3B7Flv/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interferon-gamma secretion ( J:68641 )

• stimulated CD4+ T cells secrete increased levels of Ifng compared to either DR4-transgenic or double transgenic MHC class II-deficient mice

decreased interleukin-6 secretion ( J:68641 )

• stimulated CD4+ T cells secrete low levels of Il-6 compared to either DR4-transgenic or double transgenic MHC class II-deficient mice

increased susceptibility to autoimmune diabetes ( J:68641 )

• 73% of mice expressing the transgene develop diabetes (blood glucose >250 mg/dl) compared to 0% of nontransgenic MHC class II-deficient mice

homeostasis/metabolism

increased circulating glucose level ( J:68641 )

• 73% display blood glucose levels above 250 mg/dl

increased urine glucose level ( J:68641 )

• seen in 73% of mice

renal/urinary system

increased urine glucose level ( J:68641 )

• seen in 73% of mice