Phenotypes Associated with This Genotype

Genotype
MGI:3639117

• Allelic Composition: Tg(Myh6-Akt1*T308D*S473D)1Siz/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75780 )

• survive to a mean age of 15 weeks; most die after showing signs of heart failure

cardiovascular system

abnormal myocardial fiber morphology ( J:75780 )

• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold

cardiac hypertrophy ( J:75780 )

• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age

thick ventricular wall ( J:75780 )

• significant increase in wall thickness of both the anterior and posterior left ventricular walls at 2 and 14 weeks of age

cardiac interstitial fibrosis ( J:75780 )

decreased heart left ventricle muscle contractility ( J:75780 )

• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%

muscle

abnormal myocardial fiber morphology ( J:75780 )

• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold

decreased heart left ventricle muscle contractility ( J:75780 )

• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%

growth/size/body

cardiac hypertrophy ( J:75780 )

• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age

cellular

cardiac interstitial fibrosis ( J:75780 )