Analysis Tools
cellular
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
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hematopoietic system
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
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• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
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• in lymph nodes but not in spleen
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homeostasis/metabolism
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• weight loss and increased mortality of male mutant mice is seen upon treatment with bleomycin
• severe lung injury upon bleomycin treatment is seen in male mutant mice compared with controls
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immune system
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• T cell egress from the thymus and immature B cell egress from the BM is impaired
• T and B cells showed delayed egress from lymphoid organs
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• reduction in the total leukocyte count, to 43% of the level in littermate controls
• number of cells was decreased in all leukocyte subsets examined, except for the Gr-1+ monocyte subset
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• in lymph nodes but not in spleen
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respiratory system
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• a significant increase in the size of the distal alveoli is seen in male mutant mice compared with controls
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• the air spaces of untreated adult male mutant mice are markedly enlarged, without signs of inflammation or alveolar destruction
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normal phenotype
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• mice develop normally and are fertile
• no obvious histological abnormalities are seen
• function of platelets, fibroblasts and mast cells appears similar to controls
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