Phenotypes Associated with This Genotype

Genotype
MGI:3630266

• Allelic Composition: Irf2^tm1Mak/Irf2^tm1Mak
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased memory T cell number ( J:66034 )

• activated/memory CD8+ T cells become more prominent in the spleen after 3 months and after 5 months their percentage exceeds 80%

lymph node hyperplasia ( J:66034 )

• inguinal lymph nodes have 3 times the number of cells as do wild-type and heterozygous littermates as the disease progresses

enlarged inguinal lymph nodes ( J:66034 )

• as skin diseases advances, draining lymph nodes become enlarged

dermatitis ( J:66034 )

• signs of progressive cutaneous inflammation begin as early as 8 weeks of age

hematopoietic system

increased memory T cell number ( J:66034 )

• activated/memory CD8+ T cells become more prominent in the spleen after 3 months and after 5 months their percentage exceeds 80%

integument

dermatitis ( J:66034 )

• signs of progressive cutaneous inflammation begin as early as 8 weeks of age

premature hair loss ( J:66034 )

• hair loss begins as early as 8 weeks of age and eventually extends over the entire trunk

thick epidermis ( J:66034 )

• thickening of the epidermis results from proliferation of keratinocytes in the basal epidermis

reddish skin ( J:66034 )

• homozygotes develop erythema as early as 8 weeks of age

skin lesions ( J:66034 )

• skin lesions occur, and excoriation of lesions results in ulcer formation eventually

skin fibrosis ( J:66034 )

• below the epidermis disorganization of the muscle layer and associated prominent fibrosis is seen